Which schedule includes drugs with a high potential for abuse and no accepted medical use?

The correct choice is indeed the schedule that categorizes substances with a high potential for abuse and that have no accepted medical use, which is Schedule I.

Schedule I drugs are categorized as having a significant risk for addiction and abuse, and they are not recognized for any medicinal purposes by the medical community or regulatory agencies. This schedule includes substances such as heroin and LSD, which have no accepted medical use in the United States and are considered illegal. The classification of drugs into schedules helps to regulate their availability and use, particularly concerning public health concerns.

In contrast, other schedules represent substances with varying degrees of legality and medical use. For example, Schedule II includes drugs that have a high potential for abuse but also accepted medical uses, such as oxycodone and morphine. Schedules IV and V contain drugs with lower potential for abuse and recognized medical uses, making them less strictly regulated compared to Schedule I. Thus, the unique characteristics of Schedule I make it the appropriate answer in this context.