What term describes the process of becoming used to a substance, leading to decreased effects over time?

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The process of becoming accustomed to a substance, resulting in diminished effects over time, is defined as tolerance. When an individual develops tolerance, they require increasingly larger amounts of the substance to achieve the same effects initially experienced. This phenomenon occurs as the body adapts to the presence of the drug, whether through physiological changes or receptor adjustments.

While habituation refers to a psychological adjustment to stimuli and can apply in different contexts, it does not specifically capture the physiological aspect of reduced responsiveness to a substance over time as tolerance does.

Dependency signifies a broader term encapsulating the need for a substance, which may be physical, psychological, or both, rather than the specific process of reduced effects. Withdrawal describes the symptoms that occur when a dependent individual reduces or stops substance use, which is a separate phenomenon from the gradual desensitization associated with tolerance.

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