What is a common effect of long half-life agents?

Long half-life agents are substances that remain in the body for an extended period, which influences how they affect a person's physiological and psychological states. One common effect associated with these agents is the occurrence of hangover effects. This happens because the longer duration that the substance remains active in the system can lead to prolonged aftereffects once the peak effects subside, which can include feelings of fatigue, cognitive impairment, and other withdrawal-like symptoms as the body readjusts after the substance's influence has diminished.

In contrast, immediate euphoria typically corresponds to shorter-acting substances that produce rapid onset effects. The short duration of effect is characteristic of agents that have a quick metabolism and clear from the body rapidly, which is not applicable to long half-life agents. Additionally, rapid tolerance development usually occurs more with short-acting drugs, as repeated doses lead to the body needing progressively higher amounts to achieve the same effects, rather than with long-lasting substances. These characteristics highlight why hangover effects are notably associated with long half-life agents.